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Lisa L. Cunningham, Ph.D.
Chief, Section on Sensory Cell Biology
Dr. Cunningham received a B.A. and M.A. in Audiology from the University of Tennessee, Knoxville. She completed a Clinical Fellowship in Audiology at Indiana University Medical Center in Indianapolis. She received a Ph.D. in Neuroscience from the University of Virginia and then completed a post-doctoral fellowship in Auditory Neuroscience at the University of Washington in Seattle. After her post-doc, Dr. Cunningham joined the faculty at the Medical University of South Carolina where her lab conducted the initial studies on heat shock protein (HSP)-mediated protection against ototoxic drug-induced hearing loss and hair cell death. This work was funded by a Research Project Grant (R01) from the NIDCD. Dr. Cunningham moved to the NIDCD's Section on Sensory Cell Biology in 2011.
Section on Sensory Cell Biology
Mechanosensory hair cells that are the receptor cells of hearing and balance
Selected Publications
- Baker, TG; Roy, S; Brandon, CS; Kramarenko, IK; Francis, SP; Taleb, M; Marshall, KM; Schwendener, R; Lee, F-S; Cunningham, LL (2015): Heat shock protein-mediated protection against cisplatin-induced hair cell death. J. Assoc Res Otolaryngol 16:67-80.
- Chien, WW; Monzack, EL; McDougald, D; Cunningham, LL (2015): Gene therapy for sensorineural hearing loss. Ear and Hearing 36(1):1.
- Cunningham, LL and Tucci, DL (2015): Restoring synaptic connections in the inner ear after noise damage. New England Journal of Medicine 372(2):181. Invited review.
- Wang, T; Chai, R; Kim, GS; Pham, N; Jansson, L; Nguyen, D-H; Kuo, B; May, LA; Zuo, J; Cunningham, LL; Cheng, AG (2015): Damage-recruited Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in neonatal mouse utricle. Nature Communications.
- Chien, WW; McDougald, D; Roy, S; Fitzgerald, TS; Cunningham, LL (2015): Cochlear gene transfer mediated by adeno-associated virus: comparison of two surgical approaches. Laryngoscope.
- Monzack, EL; May, LA; Roy, S; Gale, JE; Cunningham, LL (2015): Live imaging the phagocytic activity of inner ear supporting cells in response to hair cell death. Cell Death and Differentiation doi: 10.1038/cdd.2015.48.
- Drummond, MC; Barzik, M; Bird, JE; Zhang, D-S; Lechene, CP; Corey, DP; Cunningham, LL; Friedman, TB (2015): Live-cell imaging of actin dynamics reveals mechanisms of stereocilia development and homeostasis in the inner ear. Nature Communications 6:6873.
- Monzack, EL and Cunningham, LL (2013): Lead roles for supporting actors: Critical roles for inner ear supporting cells. Hearing Research 303:20-9.
- Roy, S; Ryals, MM; Botty, A; Fitzgerald, TS; Cunningham, LL (2013): Sound preconditioning therapy in mice inhibits ototoxic hearing loss. J. Clinical Investigation 123(11):4945–4949.
- May, LM; Kramarenko, II; Brandon, CS; Voelkel-Johnson, C; Roy, S; Truong, K; Francis, SP; Monzack, EL; Lee, F-S; Cunningham, LL (2013): Inner ear supporting cells protect hair cells by secreting HSP70. J. Clinical Investigation 123(8):3577–3587.
- Brandon, CS; Voelkel-Johnson, C; May, LA; Cunningham, LL (2012): Dissection of adult mouse utricle and adenovirus-mediated supporting cell infection. Journal of Visualized Experiments. 61, doi:10.3791/3734. Published online 28 March 2012.
- Francis SP; Kramarenko II; Brandon CS; Lee FS; Baker TG; Cunningham LL (2011). Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32. Cell Death & Disease 2, e195; doi:10.1038/cddis.2011.76. Published online 25 August 2011.
- Taleb, M; Brandon, CS; Lee, F-S; Harris, KC; Dillmann, WH; Cunningham, LL(2009): Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death Cell Stress Chaperones 14:427-437.