Doris K. Wu, Ph.D.

SECTION ON SENSORY CELL REGENERATION & DEVELOPMENT

NIHBC 35A - PNRC II BG RM 1D-824 35A CONVENT DR BETHESDA MD 20892

MSC:

3729

Phone:

+1 301 402 4214

Fax:

+1 301 402 5475

Email:

wud@nidcd.nih.gov

Chief, Section on Sensory Cell Regeneration and Development

Chief, Laboratory of Molecular Biology

Dr. Wu received her bachelor’s degree from the University of Wisconsin at Stevens Point, her master’s degree from the Department of Physiology at the University of Southern California, and her Ph.D. from the Department of Anatomy (currently the Department of Neurobiology) at the University of California at Los Angeles (UCLA). She received her postdoctoral training from the Mental Retardation Center (now the Intellectual and Developmental Disabilities Research Center) at UCLA and the Department of Genetics at Harvard Medical School. She joined the NIDCD in 1993 and has published many papers on the molecular mechanisms underlying inner ear development.

Laboratory:

Laboratory of Molecular Biology

Scientific Areas:

Molecular basis for the morphogenesis of the inner ear

Selected Publications

Ohta, S., Ji, Y.R., Martin, D., and Wu, D.K. Emx2 regulates hair cell rearrangement but not positional identity within neuromasts. eLife. 2021
Tona, Y. and Wu, D.K. Live imaging of hair bundle polarity acquisition demonstrates a critical timeline for transcription factor Emx2. eLife. 2020
Ono, K., Keller, J., Lopez Ramirez, O., Gonzales Garrido, A., Zobeiri, O.A., Chang, H.V., Vijayakumar, S., Ayiotis, A., Duester, G., Della Santina, C.C., Jones, S.M., Cullen, K. E., Eatock, R.A., and Wu, D.K. Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations. Nat Commun. 2020. 111(1):63 doi:10.1038/s41467-019-13710-4
Ji, Y.R., Warrier, S., Jiang, T., Wu, D.K., Kindt, K.S. Directional selectivity of afferent neurons in zebrafish neuromasts is regulated by Emx2 in presynaptic hair cells. Elife. 2018 Apr 19;7. https://doi.org/10.7554/eLife.35796
Jiang, T., Kindt, K., Wu, D.K. Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells. eLife. 2017;6:e23661. https://elifesciences.org/articles/23661
Raft, S., Andrade, L.R., Shao, D., Akiyama, H., Henkemeyer, M., Wu, D.K. Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear. Dev Biol. 390:51–67, 2014.
Evsen, L., Sugahara, S., Uchikawa, M., Kondoh H., Wu, D.K. Progression of neurogenesis in the inner ear requires inhibition of Sox2 transcription by neurogenin1 and neurod1. J Neurosci. 2013; vol33(9), pp 3879–90, 2013.
Bok, J., Zenczak, C., Hwang, C.H., Wu, D. K. Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells. PNAS, 2013, vol 110 no.34, pp.13869–13874.
Bok, J., Raft, S., Kong, K., Koo, S.K., Dräger, U.C., Wu, D.K. Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear. Proc Natl. Acad Sci. 108:161–166, 2011.
Liang, J. K., Bok, J. and Wu, D. K. Distinct contributions from the hindbrain and mesenchyme to inner ear morphogenesis. Dev Bio. 337:324–34, 2010.
Koo, S.K., Hill, J.K., Hwang C.H., Lin, Z.S., Millen, K.J., Wu, D.K. Lmx1a maintains proper neurogenic, sensory, and non-sensory domains in the mammalian inner ear. Dev Bio. 333:14–25, 2009.
Chang, W., Lin, Z., Kulessa, H., Hebert, J., Hogan, B.L.M., and Wu, D. K. Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. PLoS Genetics, 4:e1000050, 2008.
Hwang, C. and Wu, D. K. Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humans. Human Mol Genetics, 17:844–853, 2008.
Bok, J., Dolson, D. K., Hill, P., Ruther, U., Epstein, D. J. and Wu, D. K. Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development, 134:1713–1722, 2007.
Lin, Z., Cantos, R., Patente, M. and Wu, D. K. Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling. Development, 132:2309–2318, 2005.
Bok, J., Bronner-Fraser, M., and Wu, D. K. Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear. Development,132:2115–2124, 2005.
Chang, W., Brigande, J., Fekete, D. and Wu, D. K. The development of semicircular canals in the inner ear: role of FGFs in sensory cristae. Development, 131:4201–4211, 2004.
Riccomagno, M., Martinu, L., Mulheisen, M., Wu, D. K., and Epstein, D. Specification of the mammalian cochlea is dependent on Sonic hedgehog. Genes & Dev, 16:2365–2378, 2002.
Cantos, R., Cole, L., Acampora, D., Simeone, A. and Wu, D. K. Patterning of the mammalian cochlea. Proc Natl Acad Sci, 97:11707–11713, 2000.
Morsli, H., Choo D., Ryan, A., Johnson, R. and Wu, D.K. Development of the mouse inner ear and origin of its sensory organs. J Neurosci, 18:3327–3335, 1998.
Wu, D. K., Nunes, F. and Choo, D. Axial specification for sensory organs versus non-sensory structures of the chicken inner ear. Development, 125:11–20, 1998.

Last Updated Date:

April 25, 2022