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Michael Hoa, M.D.
Dr. Hoa received a B.A. from Boston University and an M.D. from Boston University School of Medicine. He completed an Otolaryngology-Head and Neck Surgery residency at Wayne State University; a Neurotology fellowship at House Ear Clinic; and a T32 USC/HRI Hearing and Communications Neuroscience Postdoctoral Research Training Fellowship. Dr. Hoa studied mechanisms responsible for the development of the organ of Corti and auditory regeneration in the laboratory of Neil Segil, Ph.D., where he used a combination of fluorescent-activated cell sorting (FACS), confocal microscopy, and live culture systems to investigate mechanisms relating to hair cell regeneration in the perinatal mouse. Along with Fred Linthicum, Saumil Merchant, and Dr. Segil, Dr. Hoa demonstrated the survival of cochlear supporting cells from human temporal bones obtained from individuals who are profoundly deaf—demonstrating that supporting cells might serve as targets for future attempts at hair cell regeneration in humans. Previous work by others has demonstrated that mammalian cochlear supporting cells can be transdifferentiated into hair cells under certain unusual conditions.
Dr. Hoa joined the NIDCD as an otolaryngology surgeon-scientist in 2013. His laboratory uses a combination of molecular biology and bioinformatics including single-cell mRNA-sequencing to examine auditory restoration in the mature cochlea utilizing adult mammalian systems.
Otolaryngology Surgeon-Scientist Program
- DeTorres A, Olszewski R, Lopez I, Ishiyama A, Linthicum F, Hoa M. Supporting cell survival after cochlear implant surgery. Laryngoscope. 2018 Oct 16. doi: 10.1002/lary.27539. [Epub ahead of print]
- Sharlin DS, Ng L, Verrey F, Visser TJ, Liu Y, Olszewski RT, Hoa M, Heuer H, Forrest D. Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10). Sci Rep 2018; 8(1):4403.
- Imtiaz A, Belyantseva IA, Beirl AJ, Fenollar-Ferrer C, Bashir R, Bukhari I, Bouzid A, Shaukat U, Azaiez H, Booth KT, Kahrizi K, Najmabadi H, Maqsood A, Wilson EA, Waryah AM, Hoa M, Dong L, Morell RJ, Smith RJH, Riazuddin S, Masmoudi S, Kindt K, Naz S, Friedman TB. CDC14A phosphatase is essential for hearing and male fertility in mouse and human. Hum Mol Genet 2018; 27(5):780-798.
- Honda K, Kim SH, Kelly MC, Burns JC, Constance L, Li X, Zhou F, Hoa M, Kelley MW, Wangemann P, Morell RJ, Griffith AJ. Molecular architecture underlying fluid absorption by the developing inner ear. Elife 2017; 6(pii):e26851. doi: 10.7554/eLife.26851.
- Nakanishi N, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay JS, Chattaraj P, Park YH, Grevich S, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ. NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy. Proc Natl Acad Sci USA 2017;114(37):E7766-E7775.
- Hoa M, Friedman RA, Fisher LM, Derebery MJ. Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere’s disease. Laryngoscope 2015 Sep 7. doi: 10.1002/lary.25579.[Epub ahead of print]
- Burns JC, Kelly MC, Hoa M, Morell RJ, Kelley MW. Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear. Nat Commun 2015;6:8557.
- Dhillon VK, Hoa M, Winter M, Wilkinson EP. Extrusion of a cochlear implant positioner through the tympanic membrane in a pediatric patient: Management of a delayed complication. Ann Otol Rhinol Laryngol 2014;123(8):537-540.
- Hoa M, Wilkinson EP, Slattery WH 3rd. Delayed recovery of speech discrimination after fractionated stereotactic radiotherapy for vestibular schwannoma in neurofibromatosis 2. Ear Nose Throat J 2014;93(2):E20-2.
- Hoa M, Linthicum FH Jr. Spiral ganglion deficiency in adult-onset deafness-dystonia syndrome. Otol Neurotol 2013;34(9):e130-1. doi: 10.1097/MAO.0b013e3182a09b3b
- Hoa M, House JW, Linthicum FH Jr., Go JL. Petrous apex cholesterol granuloma: Pictorial review of radiologic considerations in diagnosis and surgical histopathology. J Laryngol Otol 2013; 127(4):339-48.
- Friedman RA, Hoa M, Brackmann DE. Surgical management of endolymphatic sac tumors. J Neurol Surg B 2013; 74(01):012-019 DOI: 10.1055/s-0032-1329622
- Hoa M, Drazin D, Hanna G, Schwartz M, Lekovic GP. The approach to the patient with incidentally diagnosed vestibular schwannoma. Neurosurg Focus 2012; 33(3):E2.
- Hoa M, House JW, Linthicum FH Jr. Petrous apex cholesterol granuloma: Maintenance of the drainage pathway, the histopathology of surgical management, and histopathologic evidence for the exposed marrow theory. Otol Neurotol 2012; 33(6):1059-65.
- Hoa M, Slattery WH 3rd. Update on neurofibromatosis 2. Otolaryngol Clin N Am 2012; 45(2):315-32, viii.
- Wilkinson EP, Hoa M, Slattery WH 3rd, Fayad JN, Friedman RA, Brackmann DE. Evolution in the management of facial nerve schwannoma. Laryngoscope 2011; 121(10):2065-74.
- Slattery WH, Hoa M, Bonne N, Friedman RA, Schwartz MS, Fisher L, Brackman DE. Middle fossa decompression for hearing preservation: A review of institutional results and indications. Otol Neurotol 2011; 32(6):1017-24.
- Hoa M, Syamal M, Schaeffer MA, Sachdeva L, Berk R, Coticchia J. Biofilms and chronic otitis media: An initial exploration into the role of biofilms in the pathogenesis of chronic otitis media. Am J Otolaryngol 2010; 31(4):241-5.