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Dennis Drayna, Ph.D.
Chief, Laboratory of Communication Disorders
Chief, Section on Genetics of Communication Disorders
Dr. Drayna received his bachelor’s degree from the University of Wisconsin in 1976, and his Ph.D. from Harvard University in 1981, followed by postdoctoral training at the Howard Hughes Medical Institute at the University of Utah. He joined the NIDCD in 1997 and since then has focused on applying the tools of human genetics and genomics to a range of topics that span the mission of the institute, including disorders of auditory pitch perception, variation in human taste perception, and disorders of voice and speech. Dr. Drayna’s current work has a major focus on the genetics and neuroscience of stuttering.
Laboratory of Communication Disorders
Genetic linkage and positional cloning in human communication disorders.
- Raza MH, Mattera R, Morell R, Sainz E, Rahn R, Gutierrez J, Paris E, Root J, Solomon B, Brewer C, Basra MAR, Khan S, Riazuddin S, Braun A, Bonifacino J, Drayna D. Association between Rare Variants in AP4E1, a Component of Intracellular Trafficking, and Persistent Stuttering. American Journal of Human Genetics 2015; 97:715-725.
- Raza M, Domingues C, Webster R, Sainz E, Paris E, Rahn, R, Gutierrez J, Chow HM, Mundorff J, Kang C, Riaz N, Basra M, Khan S, Riazuddin S, Moretti-Ferreira D, Braun A, and Drayna D. Mucolipidosis Type II/III alpha and non-syndromic stuttering are associated with different variants in the same genes. European Journal of Human Genetics advance online publication 1 July 2015; doi: 10.1038/ejhg. 2015.154.
- Han T-U, Park J, Domingues C, Moretti-Ferreira D, Paris E, Sainz E, Gutierrez J., and Drayna D. A study of the role of the FOXP2 and CNTNAP2 genes in persistent developmental stuttering. Neurobiology of Disease 2014; 69:23-31.
- Domingues CE, Olivera CMC, Oliveira BV, Juste FS, Andrade CF, Giacheti CM, Moretti-Fereira D, Drayna D. A genetic linkage study in Brazil identifies a new locus for persistent developmental stuttering on chromosome 10. Genetics and Molecular Research 2014; 13:2094-2101.
- Raza MH, Gertz EM, Mundorff J, Lukong J, Kuster J, Schäffer A, Drayna D. Linkage analysis of a large African family segregating stuttering suggests polygenic inheritance and assortative mating. Human Genetics 2013; 132:385-396.
- Raza, MH, Ali RA, Riazuddin S, Drayna D. Studies in a consanguineous family reveal a novel locus for stuttering on chromosome 16q. Human Genetics 2012; 131:311-313.
- Lee W-S, Kang C, Drayna D, Kornfeld S. Analysis of Mannose 6-Phosphate uncovering enzyme mutations associated with persistent stuttering. Journal of Biological Chemistry 2011; 286:39786-39793.
- Raza MH, Riazuddin S, Drayna D. Identification of an autosomal recessive stuttering locus on chromosome 3q13.2-3q13.33. Human Genetics 2010; 128:461-463.
- Kang C, Riazuddin S, Mundorff J, Krasnewich D, Friedman P, Mullikin JC, Drayna D. Mutations in the lysosomal enzyme-targeting pathway and persistent stuttering. N Engl J Med. 2010 Feb 25;362(8):677-85. Epub 2010 Feb 10.
- Riaz N, Steinberg S, Ahmad J, Pluzhnikov A, Raizuddin S, Cox N, Drayna D. Genomewide significant linkage to stuttering on chromosome 12. American Journal of Human Genetics 2015; 76:647-651.