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Zhong Chen, M.D., Ph.D.
Principal Investigator, Carter Van Waes, M.D., Ph.D.
The Clinical Genomics Unit, Head and Neck Surgery Branch, was established in 2011 to investigate the structural and functional genomics of head and neck cancer. The unit currently focuses on gene expression profiles, genetic alterations, and regulatory mechanisms to identify gene signatures, pathways and networks, and biomarkers for pre-clinical and clinical trials. The unit has been conducting next generation sequencing, oligo microarray, protein array, tissue array, and RNAi screening in head and neck cancer cell lines and patients’ tumor specimens. The unit performs bioinformatics analyses of large datasets, and collaborates with The Cancer Genome Atlas (TCGA) and PanCan Atlas projects to identify common and unique genomic signatures in different cancer types, including the Pan-TCGA paper (Cell, 2014) and head and neck cancer project (Nature, 2015).
I am currently a co-chair of the PanSCC PanCan Atlas project. My research traverses several disciplines relating to translational oncology and genomics, including cell and molecular biology, gene expression and transcriptional regulation, high throughput sequencing, functional genomics, animal tumor models, preclinical and clinical investigation, and new drug testing. I have participated in pre-clinical investigations and phase 0/I clinical trials testing novel anti-cancer therapies targeting PI3K, MEK, CK2, heat shock protein, EGFR, and NF-κB pathways. My research results have appeared in approximately 100 original papers and review articles in peer-reviewed journals, and I have co-mentored about 80 Ph.D. and M.D. fellows and students.
M.D., Beijing Medical University; Ph.D., University of Rochester
Clinical Genomics Unit, Head and Neck Surgery Branch