NEUROTOLOGY BRANCH
NIHBC 35A - PNRC II BG RM 1F-123D 35A CONVENT DR BETHESDA MD 20892
MSC:
3745
Phone:
+1 301 402 3365
Email:
Education:
Ph.D., University of South Florida
Laboratory:
Neurotology Branch
Principal Investigator:
Current Projects:
Previously, our laboratory showed that estrogen replacement in ovariectomized female mice protects against noise-induced hearing loss (NIHL). We suggested that the protective effect of the estrogen is mediated through estrogen receptor 2 (ESR-2). Currently, I am investigating whether ESR-2 agonists, such as diarylpropionitrile (DPN), and selective estrogen receptor modulators (SERMs), such as raloxifene, in conjunction with FDA-approved drugs to treat high cholesterol and type II diabetes (such as statins and metformin) can be used in mice to prevent/treat NIHL.
Our research can contribute to public health since currently there is no FDA-approved treatment for NIHL.
Research Interests:
Physiological and molecular assessment of estrogen receptor agonists (such as metformin) and statins in the prevention of noise-induced hearing loss.