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Nyall R. London Jr., M.D., Ph.D.
Otolaryngology Surgeon-Scientist
Principal Investigator, Sinonasal and Skull Base Tumor Program
Dr. London is an assistant professor in the department of otolaryngology-head and neck surgery at the Johns Hopkins School of Medicine. He has an active clinical and surgical practice in Bethesda and Baltimore, Maryland, where he focuses on disorders and cancers involving the nasal cavity, sinuses, and base of the skull. In 2019, he joined the NIDCD as an investigator in the Otolaryngology Surgeon-Scientist Program, a mentored, junior-faculty career development program.
Dr. London received a bachelor’s degree in microbiology from Brigham Young University in Utah, and then an M.D. and a Ph.D. in oncological sciences from the University of Utah, Salt Lake City. During his Ph.D., under the guidance of Dr. Dean Y. Li, he received an NIH multidisciplinary cancer research training grant, which trains Ph.D. students in clinical and molecular mechanisms of cancer biology.
He then completed his otolaryngology–head and neck surgery residency training at the Johns Hopkins University School of Medicine, where he received the Frank L. Coulson Jr., Award for Clinical Excellence and the Duane Sewell Resident Award for Exemplary Professionalism and Humanitarianism. He completed a fellowship in open and endoscopic skull base surgery at The Ohio State University College of Medicine under the direction of Dr. Ricardo L. Carrau.
Otolaryngology Surgeon-Scientist Program
Selected Publications
- London NR Jr, Rooper LM, Bishop JA, Xu H, Ishii M, Taube JM, Izumchenko E, Gaykalova DA, Gallia GL. Expression of programmed cell death-ligand 1 and associated lymphocyte infiltration in olfactory neuroblastoma. World Neurosurg. 2019 Nov 27. pii: S1878-8750(19)32952-3. doi: 10.1016/j.wneu.2019.11.112. [Epub ahead of print]
- Wolfe AR, Blakaj D, London NR Jr, Blakaj A, Klamer B, Pan J, Wakely P, Prevedello L, Bonomi M, Bhatt A, Raval R, Palmer J, Prevedello D, Carrau, R. Clinical outcomes and multidisciplinary patterns of failure for olfactory neuroblastoma: The Ohio State experience. J Neurol Surg B. 2019 May 8.
- London NR Jr, Tharakan A, Mendiola M, Chen M, Dobzanski A, Sussan TE, Zaykaner M, Han AH, Lane AP, Sidhaye V, Biswal S, Ramanathan M Jr. Nrf2 activation via Keap1 deletion or sulforaphane treatment reduces Ova-induced sinonasal inflammation. Allergy. 2019 Mar 6.
- London NR Jr, Ishii M, Gallia G, Boahene K. Technique for reconstruction of large clival defects through an endoscopic-assisted tunneled retropharyngeal approach. International Forum of Allergy and Rhinology. 2018 Aug 2.
- London NR Jr, Tharakan A, Rule A, Lane A, Biswal S, Ramanathan M. Air pollutant mediated disruption of sinonasal epithelial cell barrier function is reversed by activation of the Nrf2 pathway. Journal of Allergy and Clinical Immunology. 2016 Dec;138(6):1736-1738.e4.
- Zhu W*, London NR Jr*, Gibson C*, Davis C, Tong Z, Sorensen L, Shi D, Guo J, Smith M, Grossmann A, Thomas K, Li D. Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability. Nature. 2012 Dec 13; 492(7428):252-5.
- London NR Jr*, Zhu W*, Bozza F, Smith M, Greif D, Sorensen L, Chen L, Kaminoh Y, Passi S, Day C, Barnard D, Zimmerman G, Krasnow M, Li D. Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Science Translational Medicine. 2010 Mar 17;2(23):23ra19.
- Jones C*, Nishiya N*, London NR Jr*, Zhu W, Sorensen L, Chan A, Lim C, Chen H, Zhang Q, Schultz P, Hayallah A, Thomas K, Famulok M, Zhang K, Ginsberg M, Li D. Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nature Cell Biology. 2009 Nov;11(11):1325-31.
- Jones C*, London NR Jr*, Chen H, Park K, Sauvaget D, Stockton R, Wythe J, Suh W, Larrieu-Lahargue F, Mukouyama Y, Lindblom P, Seth P, Frias A, Nishiya N, Ginsberg M., Gerhardt H, Zhang K, Li D. Robo4 stabilizes the vascular network by inhibiting pathological angiogenesis and endothelial hyperpermeability. Nature Medicine. 2008 Apr; 14(4):448-453.
*Indicates equal contribution to the work in this publication.