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Kathryn L. Ellis, Ph.D.

SECTION ON DEVELOPMENTAL NEUROSCIENCE
BG 35A RM 1D975C 35A CONVENT DR BETHESDA MD 20892
Phone: 
+1 301 435 8074
Kathryn L. Ellis
Education: 

Ph.D., Duke University 

Current Projects: 

I am broadly interested in embryonic development and organogenesis—specifically, in how developmental processes are regulated at the cellular and molecular level. The sensory epithelium of the mammalian cochlea, the organ of Corti, is composed of two types of innervated mechanosensory hair cells: the medial, afferently innervated, inner hair cells (IHCs); and the lateral, efferently innervated, outer hair cells (OHCs). IHCs and OHCs differ structurally and functionally and are separated by a single row of boundary supporting cells. The overall structure of the organ of Corti comprises an exquisitely patterned mosaic of cells whose proper differentiation and organization is critical for hearing. While many of the molecular mechanisms responsible for specification of the sensory epithelium and the hair cells are well understood, little is known about how an otherwise homogeneous prosensory domain develops into two functionally distinct domains. My work in the Laboratory of Cochlear Development seeks to understand the cellular and molecular mechanisms involved in this medio-lateral boundary formation in the developing cochlea. 

Research Interests: 
Embryonic development and organogenesis, patterning, gene editing.

Last Updated Date

October 3, 2016