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Elizabeth Driver, Ph.D.

SECTION ON DEVELOPMENTAL NEUROSCIENCE
NIHBC 35A - PNRC II BG RM 1D991B 35A CONVENT DR BETHESDA MD 20892
Phone:
+1 301 435 8074
Fax:
+1 301 480 3001
Elizabeth Driver
Education

Ph.D., Duke University

Principal Investigator
Current Projects

One of my research projects within the Section on Developmental Neuroscience is focused on cochlear morphogenesis. The mature auditory epithelium comprises hair cells and supporting cells in a highly ordered mosaic. This mosaic is formed during development by coordinated processes of cell rearrangement, cell growth, and changes in cell shape. We use live imaging of mouse embryonic cochlear explant cultures with individual fluorescently labeled cells to visualize the activity and movements of cells within the developing auditory epithelium. Time-lapse videos show that both hair cells and supporting cells exhibit considerable protrusive activity, suggesting that cochlear morphogenesis is an active—not passive—process. Continuing work on this project seeks to determine which genes regulate the many aspects of cellular movement that contribute to the formation of the auditory epithelium.

Research Interests
Cochlear development, cell fate, live imaging, cochlear morphogenesis.
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