Carmen C. Brewer, Ph.D

Selected Publications

2015

• Zalewski CK, Chien WW, King KA, Muskett JA, Baron RE, Butman JA, Griffith AJ, Brewer CC. Vestibular dysfunction in patients with enlarged vestibular aqueduct. Otolaryngol Head Neck Surg. 2015 Aug 153(2):257-62.
• Lawrence MG, Leiding JW, Lyons JJ, Hsu AP, Nelson CC, Jones N, Fitzgerald A, Chien WW, Workman L, Platts-Mills TA, Brewer C, Gafni RI, Stone KD, Milner JD, Holland SM. GATA3 haploinsufficiency does not block allergic sensitization or atopic disease. J Allergy Clin Immunol. 2015 Aug 15.
• Muskett J, Chattaraj P, Heneghan JF, Reimold FR, Shmukler BE, Brewer CC, King KA, Zalewski CK, Shawker TH, Butman JA, Kenna MA, Chien WW, Alper SL, Griffith AJ. Atypical patterns of segregation of familial enlargement of the vestibular aqueduct. Laryngoscope. 2015 Oct 20. Doe: 10.1002/lary.25737. [Epub ahead of print] PubMed PMID 26485571
• Raza M, Mattera R, Morell R, Sainz E, Rahn R, Gutierrez J, Paris E, Root J Solomon B, Brewer C, Basra MA, Khan S, Riazuddin S, Braun A, Bonfacino JS, Drayna D. Association between rare variants in AP4E1, a component of intracellular trafficking and  persistent stuttering. Am J Human Genetics. 20152015 Nov 5;97(5):715-25. doi: 10.1016/j.ajhg.2015.10.007. PubMed PMID: 26544806.
• Brewer CC, Zalewski C, King K, Zobay O, Riley A, Ferguson M, Bird J, McCabe M, Hood L, Drayna D, Griffith A, Morell R, Friedman TB, Moore DR. Heritability of non-speech auditory processing skills. European J. of Human Genetics. In press.

2014

• King KA, Gordon-Salant S, Yanjanin N, Zalewski C, Houser A, Porter FD, Brewer CC. Auditory phenotype of Niemann-Pick disease, type C1. Ear Hear. 2014 Jan-Feb;35(1):110-7.
• Chien WW, Leiding JW, Hsu AP, Zalewski C, King K, Holland SM, Brewer C. Auditory and vestibular phenotypes associated with GATA3 mutation. Otol Neurotol. 2014 Apr;35(4):577-81. 
• Olivier KN, Shaw PA, Glaser TS, Bhattacharyya D, Fleshner M, Brewer CC, Zalewski CK, Folio LR, Siegelman JR, Shallom S, Park IK, Sampaio EP, Zelazny AM, Holland SM, Prevots DR. Inhaled amikacin for treatment of refractory pulmonary nontuberculous mycobacterial disease. Ann Am Thorac Soc. 2014 Jan;11(1):30-5.
• Holliday MA, Kim HJ, Zalewski CK, Wafa T, Dewan R, King KA, Brewer CC, Butman JA, Asthagiri AR. Audiovestibular characteristics of small cochleovestibular schwannomas in neurofibromatosis type 2. Otolaryngol Head Neck Surg. 2014 Apr 8;151(1):117-124.
• King KA, Gordon-Salant S, Pawlowski KS, Taylor AM, Griffith AJ, Houser A, Kurima K, Wassif CA, Wright CG, Porter FD, Repa J, Brewer CC. Hearing loss is an early consequence of Npc1 gene deletion in the mouse model of Niemann-Pick disease, type C. J Assoc Res Otolaryngol. 2014 Aug;15(4):529-41.

2013 

• Totochny M, Tamura D, Pantell M, Zalewski C, Bradford P, Merchant S, Nadol J, Khan S, Schiffmann R, Pierson T, Wiggs E, Griffith A, DiGiovanna  J, Kraemer K, Brewer C. Auditory analysis of xeroderma pigmentosum, 1971-2012: Hearing function, acute sun sensitivity and DNA repair complementation group predict neurologic degeneration. Brain. 2013 Jan;136(Pt 1):194-208. doi: 10.1093/brain/aws317 PMID: 23365097.
• Kim HJ, Hagan M, Butman JA, Baggenstos M, Brewer C, Zalewski C, Linehan WM, Lonser RR.Surgical resection of endolymphatic sac tumors in von Hippel-Lindau disease: findings, results, and indications. Laryngoscope. 2013 Feb;123(2):477-83. 
• Viana L, Seyyedi M, Brewer CC, Zalewski C, DiGiovanna J,  Tamura D, Totonchy M, Kraemer, KH, Nadol JB Jr. Histopathology of the inner ear in patients with xeroderma pigmentosum and neurological degeneration. Otology and Neurotology. 34:1230-1236, 2013.
• Chattaraj P, Reimold FR, Muskett JA, Shmukler BE, Chien WW, Madeo AC, Pryor SP, Zalewski CK, Butman JA, Brewer CC, Kenna MA, Alper SL, Griffith AJ. Use of SLC26A4 mutation testing for unilateral enlargement of the vestibular aqueduct. JAMA Otolaryngol Head Neck Surg. 2013 Sep;139(9):907-13. PubMed PMID: 24051746.

2012

• Seaman BJ, Guardiani EA,Brewer CC, Zalewski CK, King KA, Rudy S, Van Waes C, Morgan RA, Dudley ME, Yang JC, Rosenberg SA, Kim HJ. Audiovestibular dysfunction associated with adoptive cell immunotherapy for melanoma. Otolaryngol Head Neck Surg. 2012 Oct;147(4):744-9. 
• Sibley CH, Plass N, Snow J, Wiggs EA, Brewer CC, King KA, Zalewski C, Kim HJ, Bishop R, Hill S, Paul SM, Kicker P, Phillips Z, Dolan JG, Widemann B, Jayaprakash N, Pucino, Stone DL, Chapelle D, Snyder C, Butman JA, Wesley R, Goldbach-Mansky R. Sustained response and prevention of damage progression in patients with neonatal-onset multisystem inflammatory disease treated with anakinra: a cohort study to determine three- and five-year outcomes.Arthritis Rheum. 2012 Jul;64(7):2375-86.
• Asthagiri AR, Vasquez RA, Butman JA, Wu T, Morgan K, Brewer CC, King K, Zalewski C, Kim HJ, Lonser RR. Mechanisms of hearing loss in neurofibromatosis type 2. PLoS One. 2012;7(9):e46132. 

2011

• Rehman A, Gul K, Morell R, Lee K, Ahmed Z, Riazuddin S, Ali R, Shahzad M, Jaleel, A, Andrade P, Khan SN, Khan S, Brewer C, Ahmad W, Leal S, Riazuddin S, Friedman TB. Mutations of GIPC3cause nonsyndromic deafness DFNB72but not DFNB81 that also maps to chromosome 19p,Human Genetics, e pub June 2011. 
• Ahmadi N, Brewer C, Zalewski C, King K, Butman J, Plass N., Henderson C, Goldbach-Mansky R, Kim J. Cryopyrin-Associated Periodic Syndromes (CAPS): Otolaryngologic and Audiologic Manifestations, Otolaryngology-Head and Neck Surgery, epub March 31, 2011.
• Guardiani E, Zalewski C, Brewer C,  Merideth M, Introne W, SmithACM, Gordon L, Gahl W, Kim HJ. Otologic and Audiologic Manifestations of Hutchinson-Gilford Progeria Syndrome,Laryngoscope, epub Sept 6, 2011.
• Schultz JM, Bhatti R, Madeo A, Turriff A, Muskett A, Zalewski C, King K, Ahmed  Z, Riazuddin  S, Ahmad N, Hussain Z, Qasim  M, Khan S, Meltzer M, Liu X, Munisamy M, Ghosh M, Rehm H, Tsilou E, Griffith A, Zein W, Brewer C, Riazuddin S, Friedman,TB. Allelic hierarchy of CDH23mutations causing nonsyndromic deafness DFNB12 or Usher Syndrome USH1D, Human Genetics, epub Sept 22, 2011.

2010

• Yanjanin N, Velez J, Gropman A, King K, Bianconi S, Conley S, Brewer C, Solomon B, Pavan W, Arcos-Burgos M, Patterson M, and Porter FD. Linear progression, independent of age of onset, in Niemann-Pick disease, type C. Am Journal of Medical Genetics Part B: NeuropsychiatricGenetics, 153B (1): 132-40, 2010. 
• King K, Choi BY, Zalewski C, Madeo AC, Manichaikul A, Pryor SP, Ferruggiaro A, Eisenman D, Kim HN, Niparko J, Thomsen J, Butman JA, Griffith AJ, Brewer CC. SLC26A4 genotype, but not cochlear radiologic structure, is correlated with hearing loss in ears with an enlarged vestibular aqueduct. Laryngoscope, 120(2), 384-9, 2010. 

2009

• Khan SG, Oh KS, Emmert S, Imoto K, Tamura D, Digiovanna JJ, Shahlavi T, Armstrong N, Baker CC, Neuburg M, Zalewski C, Brewer C, Wiggs E, Schiffmann R, Kraemer KH. XPC initiation codon mutation in xeroderma pigmentosum patients with and without neurological symptoms. DNA Repair (Amst). 8(1): 114-25, 2009.
• Jones JL, Zalewski C, Brewer C, Lucker J, Drayna D. Widespread auditory deficits in tune deafness. Ear Hear. Feb; 30(1):63-72, 2009.
• Choi BY, Stewart A, Madeo A, Pryor S, Lenhard S, Kittles R, Eisenman D, Kim HJ, Niparko J, Thomsen J,  Arnos K, Nance W, King K, Zalewski C, Brewer, C., Shawker T, Reynolds J, Butman J, Karniski J, Alper S, Griffith A. Hypo-functional SLC26A4 variants associated with nonsyndromic hearing loss and enlargement of the vestibular aqueduct: genotype-phenotype correlation or coincidental polymorphisms? Hum. Mutat., 2009.
• Jones, JL, Lucker, J, Zalewski C, Brewer, C, and Drayna, D. Phonological Processing In Adults with Deficits in Musical Pitch Recognition. Journal of Communciation Disorders, 42, 2009.
• Johnson L, Morgan R, Dudley M, Cassard L, Yang JC, Hughes MS, Kammula US, Royal RE, Sherry RM, Wunderlich JR, Lee CC, Restifo NP, Schwarz SL, Cogdill AP, Bishop RJ, Kim H, Brewer CC, Rudy SF, Vanwaes C, Davis JL, Mathur A, Ripley RT, Nathan DA, Laurencot CM, Rosenberg SA. Gene therapy with human and mouse t-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood, 114(3) 535-546, 2009. 
• Makishima T, King K, Brewer CC, Zalewski CK, Butman J, Bakalov VK, Bondy C, Griffith AJ.Otolaryngologic markers for the early diagnosis of Turner syndrome. Int J Pediatr Otorhinolaryngol, 73(11) 1564-7, 2009.  
• Rossi S, Hallett M, Rossini PM, Pascual-Leone A and the Safety of TMS Consensus Group [Brewer, CC, et al.]. Safety, Ethical Considerations, and Application Guidelines for the Use of Transcranial Magnetic Stimulation in Clinical Practice and Research. Clin Neurophysiol, 120(12), 2008-39, 2009.
• Choi BY, Madeo AC, King KA, Zalewski CK, Pryor SP, Muskett JA, Nance WE, Butman JA, Brewer CC, Griffith AJ. Segregation of enlarged vestibular aqueducts in families with non-diagnostic SLC26A4 genotypes. J Med Genet. 46(12):856-61, 2009.

2008

• Merideth M, Gordon L, Claus S, Sachdey V, Smith A, Perry M, Brewer C, Zalewski C, Kim HJ, Solomon B, Brooks B, Gerber L, Turner M, Domingo D, Hart T, Graf J, Reynolds J, Gropman A, Yanovski J, Collins F, Nabel E, Cannon R, Gahl W, Introne W. Hutchinson-Gilford Progeria syndrome: phenotype and course. New England Journal of Medicine, 358(6): 592-604, 2008.
• Braun A, McArdle J, Nechaev V, Zalewski,C, Brewer C, Drayna, D. Tune deafness: processing melodic errors outside of conscious awareness as reflected by components of the auditory ERP. PLoS ONE, 3(6): e2394, June 11, 2008.

2007

• Reis M, Kim J, Zalewski C, Mastrioianni M, Moore D, Brady R, Schiffman R, Brewer C. Neuropathic and cerebrovascular correlates of hearing loss in Fabry disease. Brain, 130:143-150, 2007.
• Makishima T, Madeo AC, Brewer CC, Zalewski CK, Butman JA, Sachdev V, Arai AE, Holbrook BM, Rosing DR, Griffith AJ. Nonsyndromic hearing loss DFNA10 and a novel mutation of EYA4: evidence for correlation of normal cardiac phenotype with truncating mutations of the Eya domain. American Journal of Medical Genetics, 143(14): 1592-8, 2007.
• Morell R, Brewer C, Dongliang G, Snieder H, Zalewski C, King K, Drayna D, Friedman T. A twin study of auditory processing indicates that dichotic listening ability is a strongly heritable trait.Human Genetics, 122 (1), 103-111, 2007.
• Jagannathan J, Butman JA, Lonser RR, Vortmeyer AA, Zalewski C, Brewer C, Oldfield EH, Kim HJ.Endolymphatic sac tumor demonstrated by intralabyrinthine hemorrhage. Case report.Journal of Neurosurgery, 107(2): 421-425, 2007.
• Jagannathan J, Lonser RR, Stanger RA, Butman JA, Vortmeyer AA, Zalewski C, Brewer C, Surowicz CM, Kim HJ. Cochlear implantation for hearing loss associated with bilateral endolynphatic sac tumors in von Hippel-Lindau disease. Otology and Neurotology, 28(7): 927-930, 2007.
• King K, Makishima T, Zalewski C, Bakalov, V, Griffith A, Bondy C, Brewer C. Analysis of Auditory Phenotype and Karyotype in 200 Females with Turner syndrome. Ear and Hearing, 28:831-841, 2007.
• Doherty ES, Lachbawan F, Hadley DW, Brewer C, Zalewski C, Kim HJ, Solomon B, Robenbaum K, Domingo D, Hart TC, Brooks B, Immken L, Lowry RB, Kimonis V, Shanske AL, Jehee FS, Bueno MRP, Knightley C, McDonald-McGinn D, Zacai E, Muenke M. Muenke syndrome (FGFR3) related craniosynostosis): expansion of the phenotype and review of the literature.American Journal of Medical Genetics, Part A 143A: 3204-3215, 2007.