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U.S. Department of Health & Human Services | National Institutes of Health

Braulio Peguero, Ph.D.

SECTION ON DEVELOPMENTAL NEUROSCIENCE
NIHBC 35A - PNRC II BG RM 1D-975A 35A CONVENT DR BETHESDA MD 20892
MSC:
3745
Phone:
+1 301 435 8074
Email:
Profile photo of Braulio Peguero
Education:

Ph.D., University of Washington

Laboratory:

Section on Developmental Neuroscience

Principal Investigator:
Current Projects:

The three rows of outer hair cells (OHCs) of the mammalian cochlea are a unique evolutionary development necessary for normal auditory processing. However, little is known about the genes and molecular pathways on how these cells become specified.

I’m currently working on three projects, each one aimed at understanding the role of a candidate gene in inner ear development:

  • A transcription factor expressed in maturing OHCs after postnatal age.
  • A transforming growth factor receptor responsible for developmental cellular processes expressed in early hair cell differentiation by embryonic age 14.5.
  • A transcription factor expressed in the lateral prosensory domain in cells that will differentiate to become support cells or OHCs.
Coiled sensory epithelium of the cochlea with cells labeled in green and magenta on a black background.
The spiral of the mouse cochlea at embryonic age 18.5 showing hair cells in purple and support cells in green immunolabeled with Myosin 7a and Sox2 antibodies, respectively.
A section through the organ of Corti with labeled cells on a black background.
A cryosection of the cochlea at embryonic age 18.5. Hair cells are shown in magenta and F-actin labeled in blue by phalloidin staining. After birth, Sox2 immunolabeled in green becomes restricted to the nuclei of support cells in the organ of Corti.
Research Interests:
Cellular specification of the inner ear, auditory/vestibular evoked potential, single-cell transcriptomic analysis.

Selected Publications
A complete list of publications is available at NCBI's MyBibliography.

Last Updated Date: