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Michael C. Kelly, Ph.D.
Ph.D., Emory University
My current research projects center on understanding the mechanisms that control cellular differentiation and plasticity in the developing mammalian cochlear epithelium. One major focus has been in adopting, optimizing, and utilizing cutting-edge single cell genomic techniques to gain insight into the transcriptional and epigenetic changes that occur during embryonic and postnatal development of the cochlea. This high-resolution and increasingly high-throughput information provides an opportunity to computationally reconstruct the dynamic and cell-type specific changes that occur in the generation of the highly organized auditory sensory end organ. This work aims to provide insight into the fundamental processes that direct cell fate decisions during normal development, as well as to further our understanding of what limits cell phenotype conversions.
As part of the generation of these extensive gene expression and genomic profiling experiments, I also support and contribute to the open sharing and use of these datasets. Efficient access to this data—particularly the inherently flexible single cell genomic datasets—should promote overall scientific progress as a foundational reference and potential source for meta-analysis.
With the expertise developed in single cell RNA-Seq methods, I am also involved in numerous active collaborations helping to implement single cell genomic and analysis techniques across diverse research projects in labs at the NIH and other institutions.