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Thomas B. Friedman, Ph.D.

Dr. Friedman

Chief
Laboratory of Molecular Genetics

Chief
Section on Human Genetics
Laboratory of Molecular Genetics

NIDCD/NIH
5 Research Court, Room 2A01
Rockville, MD 20850
Phone: (301) 496-7882
Fax: (301) 402-7580
E-mail: friedman@nidcd.nih.gov

Dr. Friedman received a B.S. and his Ph.D. from the University of Michigan where he worked with Tahir Mohammed Rizki on the molecular genetics of purine metabolism in Drosophila. After postdoctoral work at the NIMH, he became a faculty member in the Department of Zoology and the Department of Pediatrics and Human Development at Michigan State University. For five years he was also the Director of the Interdepartmental Graduate Program in Genetics. In 1996, he joined NIDCD as the Chief, Laboratory of Molecular Genetics. Dr. Friedman's Section on Human Genetics at the NIDCD studies hereditary hearing loss and Usher Syndrome in humans and mouse models. Dr. Friedman helped to create the NIH's Usher Syndrome Web site, a joint resource from NIDCD and the National Eye Institute.

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Laboratory of Molecular Genetics

Research Statement

Syndromic and non-syndromic hearing loss loci

Human Hearing Loss Loci
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The goal of the Laboratory of Molecular Genetics is to identify, clone and characterize the genes that contribute to communication disorders. The Section on Human Genetics is studying the genes responsible for hereditary hearing impairment and hearing loss coupled with progressive loss of vision (Usher syndrome). Improved understanding of the mutated genes will provide important information on hearing and brain processing. The identification of the relevant genes will also permit early and more accurate diagnosis for certain forms of hereditary hearing and communication impairments as well as loss of sight.

Additional research information about the identification and location of the genes for nonsyndromic and syndromic hereditary hearing loss can be found on the Hereditary Hearing Loss home page.

Subjects Needed for Research Studies

At the Laboratory of Molecular Genetics, investigators are seeking research subjects from families to participate in research studies in the following areas:

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Section on Human Genetics

Restoration of the elongation and staircase organization of abnormally short hair cell stereocilia bundles in myosin XVa mutant mice (shaker 2) and whirlin mutant mice after gene gun mediated transfection of wild-type GFP-myosin XVa and GFP-whirlin, respectively (Belyantseva et al., 2005).

Restoration of the elongation and staircase organization of abnormally short hair cell stereocilia bundles in myosin XVa mutant mice (shaker 2) and whirlin mutant mice after gene gun mediated transfection of wild-type GFP-myosin XVa and GFP-whirlin, respectively (Belyantseva et al., 2005) View larger image

Staff of the Section on Human Genetics identify and characterize dominant and recessive mutations which cause hereditary hearing impairment and Usher syndrome (hearing loss and retinal degeneration). Families from the United States, Pakistan, India and other countries are being studied to identify mutated genes that cause hereditary hearing impairment.

Lab Personnel

  • Inna A. Belyantseva, M.D., Ph.D., Research Fellow, 301-435-8204 (Send e-mail)
  • Jonathan Bird, Ph.D., Postdoc Fellow (Visiting Fellow), 301-402-3381 (Send e-mail)
  • Meghan Drummond, Ph.D., 301-435-8110 (Send e-mail)
  • Stacey Cole, B.S., Post BAC IRTA, 301-402-4209 (Send e-mail)
  • Robert J. Morell, Ph.D., Staff Scientist, 301-402-4249 (Send e-mail)
  • Barbara P. Zwiesler, M.S., Laboratory Manager, 301-402-4207 (Send e-mail)
  • Julie M. Schultz, Ph.D., Senior Research Assistant, 301-402-4208 (Send e-mail)
  • Elizabeth Wilson, B.S., Biologist, 301-402-7903 (Send e-mail)
  • Atteeq Ur Rehman, Ph.D. (Send e-mail)
  • Spencer Goodman, B.S., Post BAC IRTA, 301-402-5332 (Send e-mail)
  • Eva Morozko, B.S., Post BAC IRTA, 301-402-7565 (Send e-mail)
  • Brittany Whitley, B.S., Post BAC IRTA, 301-402-7853 (Send e-mail)
  • Chunqin Li, M.S., Biologist, 301-402-4205 (Send e-mail)

Selected Publications

Cell May 2010

Cell May 2010

Hair Cell

A noise damaged inner ear hair cell stained with antisera to gamma-actin.
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Invest Ophthalmol Vis Sci cover image

C.W. Cotterman Award
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Invest Ophthalmol Vis Sci cover image

Invest Ophthalmol Vis Sci.July 2006

Nature Cell Biology cover image

Nature Cell Biology 2005

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