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Thomas B. Friedman, Ph.D.

Dr. Friedman

Chief
Laboratory of Molecular Genetics

Chief
Section on Human Genetics
Laboratory of Molecular Genetics

NIDCD/NIH
Porter Neuroscience Research Center
35A Convent Dr., Room 1F141
Bethesda, MD 20892-3729 For U.S. Postal Service
Bethesda, MD 20814 For other carriers (FedEx, UPS, etc.)
Phone: (301) 496-7882
Fax: (301) 402-7580
E-mail: friedman@nidcd.nih.gov

Dr. Friedman received a B.S. and his Ph.D. from the University of Michigan where he worked with Tahir Mohammed Rizki on the molecular genetics of purine metabolism in Drosophila. After postdoctoral work (studying galactosemia in humans) at the National Institute of Mental Health, he became a faculty member in the Department of Zoology and the Department of Pediatrics and Human Development at Michigan State University. For five years he was also the Director of the Interdepartmental Graduate Program in Genetics. In 1996, he joined NIDCD as the Chief, Laboratory of Molecular Genetics. Dr. Friedman's Section on Human Genetics at the NIDCD studies hereditary hearing loss and Usher Syndrome in humans and mouse models. His laboratory also studies the functions (cell biology and biochemistry) of proteins encoded by genes associated with deafness. Dr. Friedman helped to create the NIH's Usher Syndrome website, a joint resource from NIDCD and the National Eye Institute.

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Laboratory of Molecular Genetics

Research Statement

Syndromic and non-syndromic hearing loss loci

Loci and genes for nonsyndromic deafness and
Usher syndrome
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The goal of the Laboratory of Molecular Genetics is to identify, clone and characterize the genes that contribute to communication disorders. The Section on Human Genetics is studying the genes responsible for hereditary hearing impairment and hearing loss coupled with progressive loss of vision (Usher syndrome). Improved understanding of the mutated genes will provide important information on hearing and brain processing. The identification of the relevant genes will also permit early and more accurate diagnosis for certain forms of hereditary hearing and communication impairments as well as loss of sight.

Additional research information about the identification and location of the genes for nonsyndromic and syndromic hereditary hearing loss can be found on the Hereditary Hearing LossThis link will open a non-federal website in a new window. home page.

Subjects Needed for Research Studies

At the Laboratory of Molecular Genetics, investigators are seeking research subjects from families to participate in research studies in the following areas:

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Restoration of the elongation and staircase organization of abnormally short hair cell stereocilia bundles in myosin XVa mutant mice (shaker 2) and whirlin mutant mice after gene gun mediated transfection of wild-type GFP-myosin XVa and GFP-whirlin, respectively (Belyantseva et al., 2005).

Restoration of the elongation and staircase organization of abnormally short hair cell stereocilia bundles in myosin XVa mutant mice (shaker 2) and whirlin mutant mice after gene gun mediated transfection of wild-type GFP-myosin XVa and GFP-whirlin, respectively (Belyantseva et al., 2005) View larger image

Section on Human Genetics

Staff of the Section on Human Genetics identify and characterize dominant and recessive mutations which cause hereditary hearing impairment and Usher syndrome (hearing loss and retinal degeneration). Families from the United States, Pakistan, India and other countries are being studied to identify mutated genes that cause hereditary hearing impairment.

Lab Personnel

Lab Personnel
Personnel (L-R, back row): Rabia Faridi, Ayesha Imtiaz, Alexis Oguh,
Joe Duda, Atteeq Ur Rehman, Jonathan Bird,
Tom Friedman, Arik Shams, Daniel Sutton, Inna A. Belyantseva;
(L-R front row): Jesse Werth, Barbara P. Zwiesler, Pat Reardon,
Elizabeth Wilson, Meghan Drummond, Melanie Barzik.

Selected Publications

Am J Hum Genet Apr 2013

Am J Hum Genet Apr 2013

Cell May 2010

Cell May 2010

Hair Cell

A noise damaged inner ear hair cell stained with antisera to gamma-actin.
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Invest Ophthalmol Vis Sci cover image

C.W. Cotterman Award
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The American Journal of Human Genetics 2010

The American Journal of Human Genetics 2010

Nature Cell Biology cover image
Nature Cell Biology 2005

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