Section on Synaptic Transmission
50 South Drive, Room 4152
Bethesda, MD 20892
Phone: (301) 496-6069
Fax: (301) 496-0190
Dr. Brenowitz received a B.A. degree in Molecular Biology from the University of California–Berkeley and a Ph.D. in Neuroscience from the University of Wisconsin–Madison, where he studied plasticity at endbulb synapses of the cochlear nucleus in the laboratory of Laurence Trussell. During a postdoctoral fellowship with Wade Regehr at Harvard Medical School, he investigated mechanisms of endocannabinoid signaling and its modulatory effects on synaptic transmission in the cerebellum. Dr. Brenowitz joined the NIDCD as an Investigator in 2007. His laboratory explores mechanisms of synaptic transmission and plasticity in the auditory system using electrophysiology, two-photon imaging and molecular techniques.
Section on Synaptic Transmission
The Section on Synaptic Transmission investigates the synaptic and biophysical mechanisms that enable neurons to encode and process information. Specifically, we study mechanisms that enable computations in neural circuits of the auditory system. The general question we address is how local circuit interactions shape a neuron's response to physiologically realistic patterns of synaptic inputs. Our approach is to examine the behavior of specific types of auditory neurons in the context of the types of inputs they receive and the information they encode, and to determine the synaptic and biophysical mechanisms that enable these computations.
The auditory system, in particular the cochlear nucleus, is an excellent system to study how the brain performs complex computations. Acoustic information is initially represented in the auditory nerve, which encodes the frequency content of sounds reaching the ears. This system provides an excellent opportunity to investigate detailed mechanisms of synaptic plasticity, neuronal integration and network function in a well-defined circuit that can be preserved experimentally in slice preparations. Because the representation of sounds by the auditory nerve and many aspects of basic auditory circuitry are relatively well-described, the behavior and function of these neural circuits can be studied in a physiologically-relevant context.
Our experimental approach combines electrophysiology and optical techniques to study synaptic transmission and plasticity in the cochlear nucleus and auditory brainstem. These studies contribute to our understanding of how sensory stimuli are represented by neuronal activity and will enable improvements in treatment of hearing disorders. More generally, the auditory system provides an ideal system for linking mechanisms of synaptic plasticity and integration to functionally-relevant coding of neural information relevant for localization, identification and interpretation of sounds.
- Ma WL, Brenowitz SD. Single-neuron Recordings from Unanesthetized Mouse Dorsal Cochlear Nucleus. J Neurophysiol. Nov 9. [Epub ahead of print], 2011.
- Sedlacek M, Tipton PW, Brenowitz SD. Sustained firing of cartwheel cells in the dorsal cochlear nucleus evokes endocannabinoid release and retrograde suppression of parallel fiber synapses. J Neurosci. Nov 2;31(44), 15807-17, 2011.
- Wang PY, Petralia RS, Wang YX, Wenthold RJ, Brenowitz SD. Functional NMDA receptors at axonal growth cones of young hippocampal neurons. J. Neurosci 31(25), 9289-97, 2011.
- Wagner W, Brenowitz SD, Hammer JA 3rd. Myosin-Va transports the endoplasmic reticulum into the dendritic spines of Purkinje neurons. Nat Cell Biol 13(1), 40-8, 2011.
- Puligilla C, Dabdoub A, Brenowitz SD, Kelley MW. Sox2 induces neuronal formation in the developing mammalian cochlea. J Neurosci 30(2), 714-22, 2010.