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NIDCD Workshop on Immune Mediated Ear Disease/Hearing Loss

July 22–23, 2008
Hyatt Regency, Bethesda, Maryland

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Agenda

Tuesday July 22, 2008

7:45–8:30 a.m. Continental breakfast
8:30–8:35 a.m. Welcome

Judith Cooper, Ph.D.
Deputy Director
Director, Division of Scientific Programs
NIDCD

8:35–8:45 a.m. Introductions and workshop overview Workshop Chair - Dennis Trune, Ph.D., Oregon Health & Science University
Background
8:45–9:15 a.m. Definitions, etiology, cardinal features, diagnosis: What constitutes autoimmune hearing loss?

Q & A

Lawrence Lustig, M.D., University of California at San Francisco

9:15–9:45 a.m. Innate immunity of the inner ear: Roles of the endolymphatic sac and spiral ligament cells

Q & A

David Lim, M.D., House Ear Institute
9:45–10:15 a.m. Discussion
10:15–10:30 a.m. Break
Cell and Antibody Immune Responses in the Ear
10:30–11:00 a.m. What evidence is there for cell mediated immune responses in the ear?

Q & A

Vincent Tuohy, Ph.D., Case Western Reserve
11:00–11:30 a.m. Antibody mediated immune processes

Q & A

Pavan Kommareddi, Ph.D., University of Michigan
11:30–noon Discussion  
Noon–1:30 p.m. Lunch (on your own)  
Systemic Immune Responses in the Ear: Alternative Paradigms: Sites of the Immune Response in the Ear
1:30–2:00 p.m. React-Respond-Repair-Restore: Is the ear directly affected by immune disease or the body's healing reaction to it?

Q & A

Dennis Trune, Ph.D., Oregon Health and Science University
2:00–2:30 p.m. Systemic inflammatory processes and biomarkers

Q & A

Andrea Vambutas, M.D., Albert Einstein College of Medicine, Long Island Jewish Medical Center
2:30–3:00 p.m. Discussion  
3:00–3:15 p.m. Break  

Infectious Agents

3:15–3:45 p.m. How can systemic infections cause hearing loss? The case of CMV

Q & A

Mark Schleiss, M.D., University of Minnesota

3:45–4:15 p.m. Discussion

Mark Schleiss, M.D., University of Minnesota

Genetic Strategies

4:15–4:45 p.m. Genetics and susceptibility loci in immune mediated hearing loss: Getting the phenotype right. Is there evidence of a heritable component?

Rick Friedman, M.D., Ph.D., House Ear Institute

4:45–5:15 p.m. Discussion

 

 

Wednesday July 23, 2008

8:00–8:30 a.m.

Continental breakfast

View from Outside Otolaryngology: Lessons to be Learned from Other Autoimmune Disorders
8:30–9:00 a.m. Successful strategies and lessons learned from other autoimmune diseases

Noel Rose, M.D., Johns Hopkins University

9:00–9:30 a.m. Basic science to clinical translation: What is needed from the industry perspective?

Vijay Kumar Ph.D., IMMCO Diagnostics, Inc., Buffalo, N.Y.

9:30–10:00 a.m. Discussion  
10:00–10:15 a.m. Break  
10:15–11:45 a.m. Identify research gaps and research needs; establish priorities  
Noon Adjourn