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Translational Research (TRANS)

Title: Translational Research
Title Code: TRANS

Purpose: NIDCD recognizes that translational research transforms scientific discovery arising from the laboratory, clinical, or population studies into clinical applications to reduce incidence of communication disorders and their burden on human health. The purpose of this supplement is to address translating basic research findings into clinical tools for improved human health in the NIDCD mission areas of hearing, balance, smell, taste, voice, speech, and language. We encourage requests for activities to increase the translation of scientific accomplishments from the laboratory to the research clinic as well as from the clinic to the clinical practitioner. The supplements are intended to provide an avenue for basic scientists, clinicians, and clinical scientists to jointly initiate and conduct pilot translational research projects. For the purposes of this supplement, a connection to a clinical condition must be clearly established and clearly stated. Supplements are expected to have both basic scientists and clinicians or clinician scientists included as key personnel; multi-institutional, multi-disciplinary, and academic-industrial collaborations are encouraged. Supplements with high potential socio-economic and health benefits are especially encouraged.

Supplement-Specific Information: Research requests must be within the scope of the parent grant and should fall under one of three broad categories: a) molecular diagnostics and therapeutics, b) bridging basic science to clinical science, and c) emergence into clinical practice. Activities may include laboratory, clinical, or community studies with human subjects as well as preclinical studies in animal models for candidate therapeutics that have previously demonstrated potential for the treatment of communication disorders. Activities may include, in addition to pilot research studies, networking activities designed to initiate and explore potential research collaborations, such as cross-site visits and workshops, between basic and clinical scientists.

Within the category of molecular diagnostics and therapeutics, activities may include, but are not limited to: systems for delivery of substances to the inner and middle ear; biochemical, electrophysiological, and behavioral assays to enhance diagnostic capabilities; pharmacology (toxicity) and pharmacokinetic studies for candidate therapeutics that have demonstrated potential for the treatment of communication disorders; dosage studies to evaluate safety, tolerability, and effectiveness of candidate therapeutics; or studies to test the efficacy of highly promising interventions in animal models of disease.

Within the category of bridging basic science to clinical science, activities may include, but are not limited to: development of tools and techniques for better diagnostics or therapeutics, including drug delivery devices, neuro-electrical stimulators, and recording devices; development of screening tests, including biomarkers, to identify individuals at risk for a disorder to allow for early intervention; moving beyond gene identification studies to studies leading to treatment for genetic defects; development and testing of new tools to better target the treatment to the individual patient and to better predict patient response or prognosis; development of sensitive and objective tools and technologies for clinical decision matrices; development and testing of innovative prevention and treatment paradigms and processes using discoveries from biological, psychological, and social sciences; development and testing of surgical techniques with the goal of providing better patient performance; development and assessment of new data collection, measurement, and recording instruments leading to better diagnostic, evaluation, and assessment paradigms; or modification of laboratory measures of function or laboratory treatment protocols for use in clinical settings.

Within the category of emergence into clinical practice, activities may include, but are not limited to: disease prevention and health promotion research (including increasing the dissemination and utilization of research evidence); increasing and promoting the use of participatory research methods (i.e., alignments with patient, provider, or advocacy groups); dissemination research; health communication research; and outcomes and quality-of-life health related research (understanding end results of health care practices and interventions, including cost-effectiveness).

Supplement Contact and Email:
Amy Donahue